Diastereoselective alkylations of oxazolidinone glycolates: a useful extension of the Evans asymmetric alkylation.
نویسندگان
چکیده
[reaction: see text] The diastereoselective alkylation of glycolate oxazolidinones has been demonstrated as a method for the enantioselective preparation of alpha-alkoxy carboxylic acid derivatives and selectively protected 1,2-diols. Various protecting groups on the glycolate hydroxyl and multiple substitution patterns on allylic iodides are tolerated in the alkylation. Yields for the alkylations are typically 70-85% with diastereoselectivities of >98:2.
منابع مشابه
Acylation, Diastereoselective Alkylation, and Cleavage of an Oxazolidinone Chiral Auxiliary: A Multistep Asymmetric Synthesis Experiment for Advanced Undergraduates
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ورودعنوان ژورنال:
- Organic letters
دوره 2 14 شماره
صفحات -
تاریخ انتشار 2000